Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response, in the airways and the lung, to noxious particles or gases. While the disease course is marked by progressive deterioration in airflow it is punctuated by acute exacerbations of COPD (AECOPD) which contribute to the overall disease severity and which increase in frequency as the disease worsens. In addition to the increased risk of morbidity and mortality associated with COPD exacerbations, these events place a significant economic burden on healthcare systems which is predicted to increase with the increasing global disease prevalence.
References: Vedel-Krogh S, Nielsen S, Lange P, Vestbo J, Nordestgaard BG . Blood Eosinophils and Exacerbations in Chronic Obstructive Pulmonary Disease. The Copenhagen General Population Study. Am J Respir Crit Care Med. 2016;193: 965–974
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